MDB has mainly studied mechanisms of control of proliferation and differentiation in eukaryotic cells using the Saccharomyces cerevisiae model, with a multidisciplinary approach to support cellular and molecular biology techniques. More recently has undertaken research concerning the effects of nutraceuticals and metabolites in the regulation of these processes. He recently proposed two models oriented to oncology. Some significant scientific results obtained with the yeast model were: i) the isolation and characterization of the GEF parent gene for Ras oncoproteins; ii) the identification of two new mechanisms that control the eukaryotic cell cycle: the one in S phase and the other in mitosis; iii) a contribution to the understanding of the mechanisms regulating the cellular dimension; iv) the demonstration that a caloric restriction mimetic molecule antagonizes specifically a powerful proliferative mechanism camp-dependent; v) the discovery that a second calorie restriction mimic molecule can have powerful anti-invecchiming effects