Immagine di MARISA BRINI

MARISA BRINI

Title: Professore associato confermato

SSD: BIO/10 - Biochemistry

Address: VIALE G. COLOMBO, 3 - PADOVA

Phone: 0498276135

E-mail: marisa.brini@unipd.it

Teaching in current academic year

Course Degree
BIOCHEMISTRY IBiology
BIOCHEMISTRY IBiotechnology

Curriculum

EDUCATION: 1985: High School final examination (Maturita’ Scientifica) 1990: B.S. degree summa cum laude at the University of Padova 1991-1992: Practical training post lauream 1992: state examination (Esame di Stato per l’Abilitazione alla Professione di Biologo) 1991-1995: Ph.D. in "Molecular and Cellular Biology and Pathology" at the University of Padova 1998-2011: Assistant Professor in Biochemistry at the University of Padova 2011-to date: Associate Professor in Biochemistry at the University of Padova 2012-to date: National Abilitation to Full Professor in Biochemistry 2016-to date: National Abilitation to Full Professor in Biochemistry HONORS, AWARDS, FELLOWSHIPS: 1990: “Consorzio Padova Ricerche” Award to thesis projects (thesis title: Molecular analysis of nuclear-encoded genes of cytochrome c oxidase of Dictyostelium discoideum). 1996: “International Human frontier Science Program“ fellowship on the topic “Control mechanisms of intracellular Ca2+ homeostasis”, on the RG-520/95 M contract of Prof. T. Pozzan. 1996-1998: "Telethon" fellowship on a project titled "Nuclear calpain in cell death with special attention to the development of muscolar distrophy", in collaboration with Prof. E. Carafoli. 2001: Accademia Nazionale dei Lincei “Fondazione Dott. Giuseppe Borgia” Award to Biological Sciences. 2003: University of Padua and Cassa di Risparmio di Padova e Rovigo “StartCup2003” First Award to Innovation. RESEARCH INTEREST Intracellular Ca2+ signalling; mitochondrial Ca2+ homeostasis and its role in aerobic metabolism; pathogenic mechanisms of mitochondrial diseases; functional analysis of Ca2+ transporting proteins in living cells, with a special attention to the plasma membrane Ca2+-ATPases; analysis of Ca2+ homeostasis in living cells carrying mutations in isoform 2 of the plasma membrane Ca2+-ATPase causing hearing loss and in isoform 3 causing cerebellar ataxia; analysis of Ca2+ homeostasis in cell model for neuromuscular and neurodegenerative diseases. Study of the Parkinson disease-related proteins (alpha-synuclein, DJ-1, parkin and PINK1) in cell signaling, calcium homeostasis, mitochondrial function and ER/mitochondria interactions. TEACHING ACTIVITY: Dr. Brini teached Biochemistry and Inorganic Chemistry (from 1998 to 2007) at the Veterinary Medicine Faculty of the University of Padua.From 2008-2014 she teached Molecular Biology at the Veterinary Medicine Faculty of the University of Padua. From 2014 she teaches Biochemistry to the students of Biotechnology and Biology at the Sciences School. From 2000 to 2013 she participated to the Teaching Committee of Doctoral School of Veterinary Medicine and since 2014 to the Teaching Committee of Doctoral School of Biosciences and acts as Tutor for PhD students.

Articles published in the last 5 years

  • Calcium, Dopamine and Neuronal Calcium Sensor 1: Their Contribution to Parkinson’s Disease
    FRONT MOL NEUROSCI
    2019
    Catoni C, Calì T, Brini M
  • Impaired mitochondrial ATP production downregulates Wnt signaling via ER stress induction
    CELL REP
    2019
    Costa R, Peruzzo R, Bachmann M, Dalla Montà G, Vicario M, Santinon G, Mattarei A, Moro E, Quintana-Cabrera R, Scorrano L, Zeviani M, Vallese F, Zoratti M, Paradisi C, Argenton F, Brini M, Calì T, Dupont S, Szabò I, Leanza L
  • A V1143F mutation in the neuronal-enriched isoform 2 of the PMCA pump is linked with ataxia
    NEUROBIOL DIS
    2018
    Vicario M, Zanni G, Vallese F, Santorelli F, Grinzato A, Cieri D, Berto P, Frizzarin M, Lopreiato R, Zonta F, Ferro S, Sandre M, Marin O, Ruzzene M, Bertini E, Zanotti G, Brini M, Calì T, Carafoli E
  • Alpha-synuclein aggregates activate calcium pump SERCA leading to calcium dysregulation.
    EMBO REP
    2018
    Betzer C, Lassen LB, Olsen A, Kofoed RH, Reimer L, Gregersen E, Zheng J, Calì T, Gai WP, Chen T, Moeller A, Brini M, Fu Y, Halliday G, Brudek T, Aznar S, Pakkenberg B, Andersen JP, Jensen PH.
  • Lipid-Mediated Modulation of Intracellular Ion Channels and Redox State: Physiopathological Implications
    ANTIOXID REDOX SIGN
    2018
    Brini M, Leanza L, Szabo I




<< 1 2 3 4 5 >>

Research area

Calcium homeostasis Analysis of the transport mechanisms of calcium ions Mitochondrial metabolism Neurodegenerative diseases

Proposals for thesis

Analysis of intracellular calcium signalling and mitochondria function in cell models expressing wt or mutant Parkinson disease- related proteins Use of recombinant tools to monitor intracellular parameters Functional analysis of the plasma membrane calcium ATPase