LUIGI LEANZA
Title: Professore associato confermato
SSD: BIO/10 - Biochemistry
Address: VIALE G. COLOMBO, 3 - PADOVA
Phone: 0498276343
E-mail: luigi.leanza@unipd.it
Teaching in current academic year
| Course | Degree |
|---|---|
| EXPERIMENTAL BIOCHEMISTRY | Molecular biology |
| BIOCHEMISTRY I | Molecular biology |
Curriculum
Group web page: http://www.bio.unipd.it/iicg/ CV pdf: https://syllabus.didattica.unipd.it/docente/CDBF98B84CCA267639F9B7A3E9A363C9/cv.pdf?tipo=ENG Dr. Luigi Leanza Assistant Professor in Biochemistry. Education: 2009: PhD in Biosciences, University of Padova 2005: Master Degree in Molecular Biology, University of Padua 2003: First Degree in Molecular Biology, University of Padua Research experiences: 2016-today: Assistant Professor, Dept. of Biology, University of Padua, Italy. 2013-16: Senior Post Doc, Dept. of Biology, University of Padua. 2009-12: Junior Research Fellow, Dept. of Biology, University of Padua. 2006-09: PhD student, Dept. of Biology, University of Padua. Research experiences abroad: 2014: EMBO Short Term Fellowship, University of Duisburg-Essen, Germany. 2013: Visiting Scientist, University of Kiel, Germany. 2004: Stage as Erasmus student, Karolinska Institute, Stockholm, Sweden. Grants: 2013-2015: Young Scientist Program, University of Padua 2012. 2017-2018: PRID2016, University of Padua. 2017: FFABR, Italian Ministry of Education. Awards: 2016: Grant for European Bioenergetic conference (EBEC), Riva del Garda, Italy. 2014: EMBO short term fellowship. 2013: Best presentation at Annual meeting of Italian Group of Bioenergetics and Biomembranes (GIBB). 2011: Travel grant for European Cell Death Organization (ECDO) conference. Patent: 2015: Co-author of an application for the patent titled “Psoralen derivatives as selective tumor-killing agents”, n. PD2015A000006, deposited the 15.01.2015. Publications: Co-author of 24 papers published in peer-reviewed journals with impact factor. First, last or corresponding author in 17 papers. Total citations: 487. H index: 12. 1. Mattarei A, et al. (2018) Front. Oncol., 8: 122. 2. Checchetto V, et al. (2018) BBRC, pii:S0006-291X(17)31226-3. 3. Brini M, et al. (2017) Antioxid. Redox Signal., in press. 4. Peruzzo R, et al. (2017) Front. in Oncol., 7: 239. 5. Venturini E, et al. (2017) Neurosignals, 25(1):26-38. 6. Leanza L, et al. (2017) Cancer Cell, 31: 516-31. 7. Zaccagnino A, et al. (2017) Oncotarget, 8(24):38276-93. 8. Peruzzo R, et al. (2016) Eur. Biophys. J., 45: 685-707. 9. Checchetto V, et al. (2016) BBA Bioenergetics, 1857: 1258-66. 10. Leanza L, et al. (2016) BBA Mol. Cell Res., 1863 (2016) 1385-1397 11. Managò A, et al. (2015) Cell Death Dis., 6: e1930. 12. Szabò I, et al. (2015) Cell. Physiol. Biochem., 37: 965-78. 13. Leanza L, et al. (2014) Cell Calcium, pii: S0143-4160(14)00143-2. 14. Leanza L, et al. (2014) Oncogene, 33: 5569-81. 15. Leanza L, et al. (2014) Current Pharmaceutical Design, 20: 189-200. 16. Leanza L, et al. (2013) Frontiers in Physiology, 4: 227. 17. Leanza L, et al. (2013) Leukemia, 27: 1782-85. 18. Leanza L, et al. (2012) Current Medicinal Chemistry, 19: 5394-5404. 19. Checchetto V, et al. (2012) Proc. Nat. Acad. Sci. USA, 109: 11043-48. 20. Leanza L, et al. (2012) EMBO Mol. Med., 4: 577-93. 21. Szabò I, et al. (2012) Pflügers Archiv - Eur. J. Phys., 463: 231-46. 22. Szabò I, et al. (2011) Cell Death Differ., 18: 427-38. 23. Leanza L, et al. (2010) Exp. Cell Res., 316: 3443-53. 24. Leanza L, et al. (2008) J. Biol. Chem., 283: 16437-45. Conferences and national or international meetings: I attended to 31 national and international congresses and in 17 of them I have been selected for an oral presentation.
Articles published in the last 5 years
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Excessive Accumulation of Ca2+ in Mitochondria of Y522S-RYR1 Knock-in Mice: A Link Between Leak From the Sarcoplasmic Reticulum and Altered Redox State
FRONT PHYSIOL2019Canato M, Capitanio P, Cancellara L, Leanza L, Raffaello A, Reane DV, Marcucci L, Michelucci A, Protasi F, Reggiani C -
Impaired mitochondrial ATP production downregulates Wnt signaling via ER stress induction
CELL REP2019Costa R, Peruzzo R, Bachmann M, Dalla Montà G, Vicario M, Santinon G, Mattarei A, Moro E, Quintana-Cabrera R, Scorrano L, Zeviani M, Vallese F, Zoratti M, Paradisi C, Argenton F, Brini M, Calì T, Dupont S, Szabò I, Leanza L -
Inhibition of PI-3-K and AKT Amplifies Kv1.3 Inhibitor-Induced Death of Human T Leukemia Cells
CELL PHYSIOL BIOCHEM2019Bergermann T, Born L, Ferguson F, Latkovic P, Scheul A, Sonnenschein N, Leanza L, Keitsch S, Sehl C, Wilker B, Edwards MJ, Zoratti M, Paradisi C, Kohnen M, Szabo I, Becker KA, Carpinteiro A -
Targeting the Mitochondrial Potassium Channel Kv1.3 to Kill Cancer Cells: Drugs, Strategies, and New Perspectives
SLAS DISCOV2019Prosdocimi E, Checchetto V, Leanza L. -
Lipid-Mediated Modulation of Intracellular Ion Channels and Redox State: Physiopathological Implications
ANTIOXID REDOX SIGN2018Brini M, Leanza L, Szabo I
Research area
The main topic of our research activity is focused on the study of intracellular ion channels as new oncological targets. Several reports have demonstrated that ion channels show an altered expression in several tumor tissues compared to normal ones, suggesting their targeting as a new strategy to eliminate cancer cells. We have recently demonstrated that the pharmacological targeting of a mitochondrial potassium channel, mitoKv1.3, can selectively eliminate cancer cells in vitro, using several cancers cell lines, ex-vivo, using primary cells obtained from patients, and in vivo, using pre-clinical mouse models for melanoma and pancreatic ductal adenocarcinoma (Leanza et al. Cancer Cell 2017). We have several collaborations with other research groups both in Padova and in Europe and USA.
Proposals for thesis
Gli argomenti di tesi riguardano lo studio dei canali ionici mitocondriali e del loro ruolo nella tumorigenesi. Le tecniche che si possono apprendere in laboratorio riguardano la biologia cellulare, molecolare, la biochimica, oltre ad esperimenti in vivo su modelli di Zebrafish e di topo.
