LUCA SCORRANO
Title: Professore ordinario
SSD: BIO/10 - Biochemistry
Address: VIA U. BASSI, 58/B - PADOVA
Phone: 0498276320
E-mail: luca.scorrano@unipd.it
Teaching in current academic year
Course | Degree |
---|---|
BIOCHEMISTRY OF DISEASES | Molecular Biology |
BIOCHEMISTRY OF DISEASES | Sanitary Biology |
Curriculum
The work of L. Scorrano addresses the central question of form-function relationship at the molecular level. During his career, he has changed classical tenets in the fields of apoptosis, mitochondrial pathophysiology, and medicine. His work on cristae remodeling paved the way for the new field of mitochondrial dynamics. In the following years, his lab discovered that Opa1 works as a molecular staple holding cristae junctions tight, deficient in dominant optic atrophy, targeted during apoptosis and essential in vivo to control tissue damage and to correct mitochondrial diseases, as well as a key factor in angiogenesis that can be pharmacologically targeted to curtail tumor growth; identified the first molecular bridge between ER and mitochondria (propelling the new field of interorganellar contact sites); showed that mitochondria change shape to control autophagy, or to produce progesterone during pregnancy; demonstrated that cristae shape dictates assembly of proteins and efficiency of respiration; discovered a novel pathway of Notch1 signaling controlled by mitochondrial fusion and Ca2+ essential during heart development; discovered that mitochondrial fusion mounts a metabolic defense against Toxoplasma. His papers are widely cited (192 indexed items, approx. 57,000 citations, h-index of 88 on Google Scholar; of his original research papers as main author, 9 are cited >1,000 times, 15 >300 times), leading to his inclusion in the Clarivate Highly Cited Researchers list in 2021 and 2022. For his research, he received several international awards and was elected EMBO Member in 2012 and member of the Academia Europaea in 2019.
Curriculum in PDF: English CV
Articles published in the last 5 years
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MCUB Hearts Mitochondria in Sickness, Less in Health
CIRCULATION2019Kaludercic N, Scorrano L -
PARP Inhibitor PJ34 Protects Mitochondria and Induces DNA-Damage Mediated Apoptosis in Combination With Cisplatin or Temozolomide in B16F10 Melanoma Cells
FRONTIERS IN PHYSIOLOGY2019Cseh A, Fabian Z, Quintana Cabrera R, Szabo A, Eros K, Soriano M, Gallyas F, Scorrano L, Sumegi B -
Proteasome dysfunction induces excessive proteome instability and loss of mitostasis that can be mitigated by enhancing mitochondrial fusion or autophagy
AUTOPHAGY2019Tsakiri EN, Gumeni S, Vougas K, Pendin D, Papassideri I, Daga A, Gorgoulis V, Juhasz G, Scorrano L, Trougakos IP -
Single cell analysis reveals the involvement of the long non-coding RNA Pvt1 in the modulation of muscle atrophy and mitochondrial network.
NUCLEIC ACIDS RES2019Alessio E, Buson L, Chemello F, Peggion C, Grespi F, Martini P, Massimino ML, Pacchioni B, Millino C, Romualdi C, Bertoli A, Scorrano L, Lanfranchi G, Cagnin S -
Too close not to encyst: Polycystic kidney disease and interorganellar contact sites
SCIENCE SIGNALING2019Lorenzi I, Scorrano L
Research area
Mitochondrial dynamics in cell life, differentiation and death
Proposals for thesis
Mitochondrial dynamics in cell life and death