LUCA SCORRANO
Title: Professore ordinario
SSD: BIO/10 - Biochemistry
Address: VIA U. BASSI, 58/B - PADOVA
Phone: 0498276320
E-mail: luca.scorrano@unipd.it
Teaching in current academic year
Course | Degree |
---|---|
BIOCHEMISTRY OF DISEASES | Molecular Biology |
BIOCHEMISTRY OF DISEASES | Sanitary Biology |
Curriculum
The work of L. Scorrano addresses the central question of form-function relationship at the molecular level. During his career, he has changed classical tenets in the fields of apoptosis, mitochondrial pathophysiology, and medicine. His work on cristae remodeling paved the way for the new field of mitochondrial dynamics. In the following years, his lab discovered that Opa1 works as a molecular staple holding cristae junctions tight, deficient in dominant optic atrophy, targeted during apoptosis and essential in vivo to control tissue damage and to correct mitochondrial diseases, as well as a key factor in angiogenesis that can be pharmacologically targeted to curtail tumor growth; identified the first molecular bridge between ER and mitochondria (propelling the new field of interorganellar contact sites); showed that mitochondria change shape to control autophagy, or to produce progesterone during pregnancy; demonstrated that cristae shape dictates assembly of proteins and efficiency of respiration; discovered a novel pathway of Notch1 signaling controlled by mitochondrial fusion and Ca2+ essential during heart development; discovered that mitochondrial fusion mounts a metabolic defense against Toxoplasma. His papers are widely cited (192 indexed items, approx. 57,000 citations, h-index of 88 on Google Scholar; of his original research papers as main author, 9 are cited >1,000 times, 15 >300 times), leading to his inclusion in the Clarivate Highly Cited Researchers list in 2021 and 2022. For his research, he received several international awards and was elected EMBO Member in 2012 and member of the Academia Europaea in 2019.
Curriculum in PDF: English CV
Articles published in the last 5 years
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Functional wiring of proteostatic and mitostatic modules ensures transient organismal survival during imbalanced mitochondrial dynamics
REDOX BIOLOGY2019Gumeni S, Evangelakou Z, Tsakiri EN, Scorrano L, Trougakos IP -
Hyperactivation of Nrf2 increases stress tolerance at the cost of aging acceleration due to metabolic deregulation
AGING CELL2019Tsakiri EN, Gumeni S, Iliaki KK, Benaki D, Vougas K, Sykiotis GP, Gorgoulis VG, Mikros E, Scorrano L, Trougakos IP -
Impaired mitochondrial ATP production downregulates Wnt signaling via ER stress induction
CELL REP2019Costa R, Peruzzo R, Bachmann M, Dalla Montà G, Vicario M, Santinon G, Mattarei A, Moro E, Quintana-Cabrera R, Scorrano L, Zeviani M, Vallese F, Zoratti M, Paradisi C, Argenton F, Brini M, Calì T, Dupont S, Szabò I, Leanza L -
Inhibition of the deubiquitinase USP8 corrects a Drosophila PINK1 model of mitochondria dysfunction
LIFE SCIENCE ALLIANCE2019von Stockum S, Sanchez-Martinez A, Corrà S, Chakraborty J, Marchesan E, Locatello L, Da Rè C, Cusumano P, Caicci F, Ferrari V, Costa R, Bubacco L, Rasotto MB, Szabo I, Whitworth AJ, Scorrano L, Ziviani E -
Inhibition of the Fission Machinery Mitigates OPA1 Impairment in Adult Skeletal Muscles
CELLS2019Romanello V, Scalabrin M, Albiero M, Blaauw B, Scorrano L, Sandri M
Research area
Mitochondrial dynamics in cell life, differentiation and death
Proposals for thesis
Mitochondrial dynamics in cell life and death