Immagine di LUCA SCORRANO

LUCA SCORRANO

Title: Professore ordinario

SSD: BIO/10 - Biochemistry

Address: VIA U. BASSI, 58/B - PADOVA

Phone: 0498276320

E-mail: luca.scorrano@unipd.it

Teaching in current academic year

Course Degree
BIOCHEMISTRY OF DISEASES
BIOCHEMISTRY OF DISEASESSanitary Biology

Curriculum

The work of L. Scorrano has changed classical tenets in the fields of apoptosis and mitochondrial pathophysiology. His work on cristae remodeling paved the way for the new field of mitochondrial dynamics. In the following years, his lab discovered that Opa1 works as a molecular staple holding cristae junctions tight, deficient in dominant optic atrophy, targeted during apoptosis and essential in vivo to control tissue damage and even to correct mitochondrial diseases; identified the first molecular bridge between ER and mitochondria (starting the new field of interorganellar contact sites); showed that mitochondria change shape to control autophagy, or to produce progesterone during pregnancy; demonstrated that cristae shape dictates assembly of proteins and efficiency of respiration; discovered a novel pathway of Notch1 signaling controlled by mitochondrial fusion and Ca2+ essential during heart development; discovered that mitochondrial fusion mounts a metabolic defense against the intracellular parasite Toxoplasma. His papers are widely cited (146 indexed items, approx. 22,000 citations, average of ~150 cites/item, h-index of 68 on Google Scholar; of his research papers as main author, 3 are cited >1,000 times, 11 >300 times, 21 >100 times). For his research, he received several awards and was elected EMBO Member in 2012. L. Scorrano serves the community by sitting on advisory, steering and evaluation boards in Europe and abroad.

Curriculum in PDF: English CV

Articles published in the last 5 years

  • Coming together to define membrane contact sites
    NATURE COMMUNICATIONS
    2019
    Scorrano L, De Matteis M, Emr S, Giordano F, Hajnoczky G, Kornmann B, Lackner LL, Levine TP, Pellegrini L, Reinisch K, Rizzuto R, Simmen T, Stenmark H, Ungermann C, Schuldiner M
  • Finding a new balance to cure Charcot-Marie-Tooth 2A
    JOURNAL OF CLINICAL INVESTIGATION
    2019
    Iwata K, Scorrano L
  • Hyperactivation of Nrf2 increases stress tolerance at the cost of aging acceleration due to metabolic deregulation
    AGING CELL
    2019
    Tsakiri EN, Gumeni S, Iliaki KK, Benaki D, Vougas K, Sykiotis GP, Gorgoulis VG, Mikros E, Scorrano L, Trougakos IP
  • Impaired mitochondrial ATP production downregulates Wnt signaling via ER stress induction
    CELL REP
    2019
    Costa R, Peruzzo R, Bachmann M, Dalla Montà G, Vicario M, Santinon G, Mattarei A, Moro E, Quintana-Cabrera R, Scorrano L, Zeviani M, Vallese F, Zoratti M, Paradisi C, Argenton F, Brini M, Calì T, Dupont S, Szabò I, Leanza L
  • PARP Inhibitor PJ34 Protects Mitochondria and Induces DNA-Damage Mediated Apoptosis in Combination With Cisplatin or Temozolomide in B16F10 Melanoma Cells
    FRONTIERS IN PHYSIOLOGY
    2019
    Cseh A, Fabian Z, Quintana Cabrera R, Szabo A, Eros K, Soriano M, Gallyas F, Scorrano L, Sumegi B




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Research area

Mitochondrial dynamics in cell life, differentiation and death

Proposals for thesis

Mitochondrial dynamics in cell life and death