

FEDERICA SANDRELLI
Title: Professore associato confermato
SSD: BIO/18 - Genetics
Address: VIA U. BASSI, 58/B - PADOVA
Phone: 0498276216
E-mail: federica.sandrelli@unipd.it
Teaching in current academic year
Course | Degree |
---|---|
GENETICS | |
GENETICS | Biotechnology |
BEHAVIOURAL GENETICS | Evolutionary biology |
BEHAVIOURAL GENETICS | Molecular Biology |
Curriculum
EDUCATION • Degree in Biology (110/110 cum laude,University of Padova), 1992 • PhD in Genetics (University of Ferrara; Consortium among Universities of Bologna, Ferrara, Padova, Parma and Pisa), 1998 PROFESSIONAL EXPERIENCE • Post graduate fellow of ”Associazione Italiana Ricerca sul Cancro” (AIRC) at the Department of Biology, University of Padova, 1993-1994 • PhD student in Genetics (University of Ferrara; Consortium among Universities of Bologna, Ferrara, Padova, Parma and Pisa), 1994-1997. • Erasmus PhD student at the Department of Genetics, University of Leicester, UK, 1995 • Postdoc (University Hospital, Univeristy of Padova), 1997-1999 • Assistant Professor (Genetics) (University of Padova), 1999-2011 • Associate Professor (Scientific Disciplinary Sector BIO/18-Genetics) at the University Padova, Department of Biology, 2011-present • Visiting Scientist (University of Fribourg, Fribourg (CH)), 2012-2013 RESEARCH ACTIVITY 1) Circadian control of the innate immune response in Bombyx mori and Drosophila melanogaster insects. 2) Mechanisms of action of specific antimicrobial peptides, candidates as potential drugs; 3) Generation of insects effectively reducing PET plastic waste (Project in collaboration with Prof. G. Tettamanti, University of Insubria, Varese). This project aims to generate black soldier fly larvae, Hermetia illucens, capable of efficiently expressing PET catabolic enzymes in the midgut. It involves the study of modified microbial PET-degrading enzymes in insect cell lines, transgenic D. melanogaster flies and the generation of knock-in black soldier larvae for PET-degrading enzymes, using a CRISPR/Cas9 methodology. 4) D. melanogaster as a model organism for the study of Parkinson's disease. Projects in collaboration with Prof. Marco Bisaglia (DiBio, Unipd) and aimed at studying the genes of D. melanogaster, homologous to human genes related to Parkinson's disease, performing both molecular and behavioral analyses. TEACHING ACTIVITY •"Genetics" for the three-year degree courses in Molecular Biology and Natural and Environmental Sciences, Dept of Biology, University of Padova 2023-2024 • "Genetics" for the three-year degree courses in Biotechnology and Natural Sciences, Department of Biology, University of Padova 2000-2023 “Behavioral Genetics” for the Master degrees Evolutionary Biology and Molecular Biology, University of Padova 2021-present • Invited Professor in the “Spring school of Chronobiology” for PhD students in Haren, Netherlands, June 2004. • She acquired the Teaching4Learning Badge from University of Padova, 2018 • Tutor/supervisor of several theses for Bachelor and Master degrees • Supervisor of 4 PhD students and 4 PostDocs. BOARD OF PhD PROGRAMS • Member of the board of professors of the PhD School in “Biosciences”, Curriculum “Genetics Genomics and Bioinformatics”, University of Padova, 2018 • Member of the board of professors of the PhD School of “Biosciences and Biotechnology”, Curriculum “Genetics and Developmental Molecular Biology”, University of Padova 2009-2015.
Curriculum in PDF: English CV
Articles published in the last 5 years
-
Antioxidant therapy in Parkinson’s disease: Insights from Drosophila melanogaster
ANTIOXIDANTS-BASEL2020De Lazzari F, Sandrelli F, Whitworth AJ, Bisaglia M -
Arginine kinase interacts with 2MIT and is involved in Drosophila melanogaster short-term memory
J INSECT PHYSIOL2020Bozzato A, Romoli O, Polo D, Baggio F, Mazzotta GM, Triolo G, Myers MP, Sandrelli F -
Enhanced Silkworm Cecropin B Antimicrobial Activity against Pseudomonas aeruginosa from Single Amino Acid Variation
ACS INFECT DIS2019Romoli O, Mukherjee S, Mohed SA, Dutta A, Montali A, Franzolin E, Brady D, Zito F, Bergantino E, Rampazzo C, Testamenti G, Bhutia A, Sandrelli F -
Insect Cecropins, Antimicrobial Peptides with Potential Therapeutic Applications
INT J MOL SCI2019Brady D, Grapputo A, Romoli O, Sandrelli F -
Circadian Rhythm Abnormalities in Parkinson's Disease from Humans to Flies and Back
INT J MOL SCI2018De Lazzari F, Bisaglia M, Zordan MA, Sandrelli F
Research area
Main research topics: 1) Circadian control of the innate immune response in the insects Bombyx mori and Drosophila melanogaster. 2) Mechanisms of action of specific antimicrobial peptides, candidates as potential drugs; 3) Analysis of behavioral genes (circadian and non-circadian) in Drosophila melanogaster. This type of research is focused on the molecular and functional study of behavioral genes in the fruit fly Drosophila melanogaster, using strategies based on behavioral analysis, generation of transgenics, and molecular analyses.
Proposals for thesis
Bachelor and Master Degree theses will be focussed on the following research topics: 1) Circadian control of the innate immune response in the insects Bombyx mori and Drosophila melanogaster. 2) Mechanisms of action of specific antimicrobial peptides, candidates as potential drugs; 3) Generation of insects effectively reducing PET plastic waste