

MARINA DE BERNARD
Title: Professore ordinario
SSD: MED/04 - General Pathology
Address: VIA U. BASSI, 58/B - PADOVA
Phone: 0498276309
E-mail: marina.debernard@unipd.it
Teaching in current academic year
Course | Degree |
---|---|
PATHOLOGY AND HISTOPATHOLOGY | Health Biology |
MOLECULAR PATHOLOGY | Sanitary Biology |
Curriculum
Curriculum in PDF: English CV
Articles published in the last 5 years
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Helicobacter pylori Dampens HLA-II Expression on Macrophages via the Up-Regulation of miRNAs Targeting CIITA
FRONTIERS IN IMMUNOLOGY2020Codolo G, Toffoletto M, Chemello F, Coletta S, Teixidor G, Battaggia G, Munari G, Fassan M, Cagnin S, De Bernard M -
The immune receptor CD300e negatively regulates T cell activation by impairing the STAT1-dependent antigen presentation
SCI REP-UK2020Coletta S, Salvi V, Della Bella C, Bertocco A, Lonardi S, Trevellin E, Fassan M, D'Elios MM, Vermi W, Vettor R, Cagnin S, Sozzani S, Codolo G, de Bernard M -
Simulating Inflammation in a Wound Microenvironment Using a Dermal Wound-on-a-Chip Model
ADVANCED HEALTHCARE MATERIALS2019Biglari S, Le TYL, Tan RP, Wise SG, Zambon A, Codolo G, De Bernard M, Warkiani M, Schindeler A, Naficy S, Valtchev P, Khademhosseini A, Dehghani F -
Supercritical carbon dioxide combined with high power ultrasound as innovate drying process for chicken breast
J SUPERCRIT FLUID2019Morbiato G, Zambon A, Toffoletto M, Poloniato G, Dall'Acqua S, de Bernard M, Spilimbergo S -
The lipoprotein HP1454 of Helicobacter pylori regulates T-cell response by shaping T-cell receptor signalling
CELLULAR MICROBIOLOGY2019Capitani N, Codolo G, Vallese F, Minervini G, Grassi A, Cianchi F, Troilo A, Fischer W, Zanotti G, Baldari CT, De Bernard M, D'Elios MM
Research area
Our research area focuses on understanding the mechanisms that modulate the immune system, involving the regulation of specific functions that can either activate or suppress them. These mechanisms have evolved in many pathogens as strategies to evade the immune response. However, they also play a crucial role in various diseases where the immune-inflammatory aspect serves a critical function, such as in obesity. In this condition, a state of chronic inflammation develops, playing a pivotal role in the metabolic dysfunction associated with obesity, often linked to the development of type II diabetes. Our most recent research is centered on investigating the role of a receptor whose expression in adipose tissue increases in response to overnutrition conditions. We examine how this receptor influences the processes of adipose tissue remodeling, glycemic homeostasis, and inflammation associated with obesity.
Proposals for thesis
The research proposals for thesis projects include: i) identifying the physiological ligand of an immunoreceptor whose expression increases in adipose tissue under conditions of obesity (please refer to the 'Research Areas' section) and analyzing the signal cascade it triggers; ii) studying the immunomodulatory role of the receptor and its impact on the insulin resistance condition that precedes the development of type II diabetes. During the thesis work, students will have the opportunity to learn various techniques, including: isolation of monocytes from peripheral blood, gene silencing, flow cytometry, gel electrophoresis, western blot, immunoprecipitation, qRT-PCR from RNA isolated from cells and tissues, ELISA assays, and immunohistochemistry.