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DIPARTIMENTO DI BIOLOGIA (DiBio) - Università degli Studi di Padova

DIPARTIMENTO DI BIOLOGIA (DiBio) - Università degli Studi di Padova

DIPARTIMENTO DI BIOLOGIA (DiBio)

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Immagine di MADDALENA MOGNATO

MADDALENA MOGNATO

Title: Professore associato confermato

SSD: BIO/06 - Comparative Anatomy and Citology

Address: VIA U. BASSI, 58/B - PADOVA

Phone: 0498276274

E-mail: maddalena.mognato@unipd.it

Teaching in current academic year

Course Degree
HISTOLOGY, EMBRIOLOGY AND DEVELOPMENTMolecular biology
CELLS BIOLOGYMolecular biology

Curriculum

Associate professor of Cell Biology with a Ph.D in Environmental Medicine. Her research activity is focused on cytotoxic and genotoxic effects induced in human cells by ionizing (gamma/X rays, low energy protons) and non-ionizing radiation(laser light, UV light), chemicals (nanoparticles, cisplatin, polycyclic aromatic hydrocarbons). She took part to projects funded by the Italian Space Agency to study the effects of ionizing radiation associated to modeled microgravity, focusing on DNA repair, in particular on that of double strand breaks (DSBs). She collaborated at european projects to study the cytotoxic effects and the mechanisms of action of different nanomaterials and to study the biological properties of nanosystems formuled to delivery drugs or other antineoplastic compounds, to improve selectivity and efficacy of antitumoural therapy. She collaborated with Istituto Oncologico Veneto (IOV) of Padova, the Department of Molecular Medicine and the laboratories INFN of Legnaro (PD) at the project:“Individual response to radiotherapy: looking at molecular biomarkers of radiosensitivity/radioresistance”. Since several years she studies the role of microRNA (miRNAs) as modulators of gene expression during the cell response to IR and their use as radiosensitizing agents for radioresistant human cancer cells. Her research activity is documented in international paper with referee. She participated to many international and national conferences. She has been responsible of financial grants of Padova University.

Curriculum in PDF: English CV

Articles published in the last 5 years

  • Individual radiosensitivity in oncological patients: linking adverse normal tissue reactions and genetic features
    FRONT ONCOL
    2019
    Palumbo E, Piotto C, Calura E, Fasanaro E, Groff E, Busato F, El Khouzai B, Rigo M, Baggio L, Romualdi C, Zafiropoulos D, Russo A, Mognato M, Corti L
  • Tumor-facing hepatocytes significantly contribute to mild hyperthermia-induced targeting of rat liver metastasis by PLGA-NPs
    INT J PHARM
    2019
    Castellani C, Fedrigo M, Tavano R, Cappellini R, Fedeli C, Mognato M, Abdel-Mottaleb MMA, Lamprecht A, Tudorancea I, Porumb V, Iliescu R, Angelini A, Papini E, Dimofte G
  • Functional validation of miRNAs targeting genes of DNA double-strand break repair to radiosensitize non-small lung cancer cells
    BBA-GENE REGUL MECH
    2018
    Piotto C, Biscontin A, Millino C, Mognato M
  • Robust and Biocompatible Functionalization of ZnS Nanoparticles by Catechol-Bearing Poly(2-Methyl-2-Oxazoline)s.
    LANGMUIR
    2018
    De Fazio AF, Morgese G, Mognato M, Piotto C, Pedron D, Ischia G, Causin V, Rosenboom JG, Benetti EM, Gross S.
  • Analysis of DNA-Damage Response to ionizing radiation in serum-shock synchronized human fibroblasts
    CELL BIOL TOXICOL
    2017
    Corrà S, Salvadori R, Bee L, Barbieri V, Mognato M




Research area

•Study of the DNA-Damage Response to ionizing radiation of different qualities (gamma/X rays, low energy protons)in human primary cells (lymphocytes, fibroblasts) and cancer cells (lymphoblastoid,cells derived from lung carcinoma, etc.) •Role of miRNAs in DNA-Damage Response to radiation. Analyses of miRNA and mRNA expression profiles in human cells irradiated in vitro with gamma rays. Over-expression of miRNAs targeting crucial genes of homologous and non-homologous recombination of DSB repair. •Identification of molecular biomarkers of individual radiosensitivity in oncological patients under radiotherapy. •Nanotoxicology. Analysis of in vitro toxicity of silica nanoparticles (Ormosil; Ludox), of liposomes and functionalized zinc nanostructures (ZnS).

Proposals for thesis

1. "Role of microRNAs in the DNA-Damage Response (DDR) to ionizing radiation ". MiRNAs are small non coding RNAs acting as post-transcriptional regulators of gene expression by binding to complementary 3’UTR of their target mRNA and causing mRNA translational repression or destabilization and decay; as a consequence miRNAs reduce the expression of target genes. DDR allows DNA damage detection, signal propagation and transduction to a multitude of effector proteins, which promote cell survival, activate cell cycle arrest to allow DNA repair, or apoptosis when cells are unable to properly repair DNA. DDR is regulated at both transcriptional and post-transcriptional level. More than half of DDR genes contain conserved miRNA target sites. 2. "Individual response to radiotherapy: identification of molecular biomarkers ".The study aims at defining a genetic signature of genes of the DNA Damage Response (DDR) pathway to define different degrees of patient radiosensitivity. Individual gene expression data from blood samples isolated from patients undergoing radiotherapy are integrated with clinical evaluation of tissue radio-sensitivity and with cytogenetic analyses in vitro. The research project is in collaboration with the Istituto Oncologico Veneto IOV-IRCCS (UOC of Radiotherapy), and with colleagues of the Dept. of Biology and Molecular Medicine of Padova University.

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Viale G. Colombo 3
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Via U.Bassi 58/ B
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35131 Padova
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Fax +39 049 807 2213
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