

ALESSANDRA RAMPAZZO
Title: Professore ordinario
SSD: BIO/13 - Applied Biology
Address: VIA U. BASSI, 58/B - PADOVA
Phone: 0498276208
E-mail: alessandra.rampazzo@unipd.it
Teaching in current academic year
Course | Degree |
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APPLIED MOLECULAR GENETICS | Health Biology |
Curriculum
Education March 1991 Degree in Biological Sciences at the University of Padova July 1997 PhD in Genetics at the University of Ferrara December 2004 Post-graduate school in Medical Genetics at the University of Padova. Academic appointments December 2002 Assistant professor in Applied Biology at Department of Biology, University of Padova October 2010 Associate professor in Applied Biology, at Department of Biology, University of Padova October 2017 Full professor in Applied Biology, at Department of Biology, University of Padova Teaching activities Graduate Course in Health Biology and in Food Science and Technologies PhD Course in Cardiosciences and Biosciences Research fields Molecular genetics of cardiomyopathies, with particular reference to Arrhythmogenic Cardiomyopathy (AC or ARVC), which is a common cause of juvenile sudden death among athletes. Both biologist and medical genetist, working in the field of molecular genetics since 1992, she was involved in mapping four loci and in identifying five novel AC genes. These findings allowed the employment of mutation screening for carrier detection among family members of affected subjects and played an essential role in sudden death prevention and genetic counseling. In the last years, she moved from molecular genetics studies to functional studies to unveil molecular mechanisms involved in the pathogenesis of inherited cardiomyopathies through generation of animal models. Selected research achievements: -1994 Mapping of the first AC locus -2001 Identification of the gene involved in ARVD2 (RYR2 gene) -2002 Mapping and identification of the gene involved in ARVD8 (DSP gene) -2005 Identification of the gene involved in ARVD1 (TGFbeta3 gene) -2006 Identification of the gene involved in ARVD10 (DSG2 gene) -2012 Identification of a novel AC gene (CTNNA3 gene) Publications https://scholar.google.it/scholar?hl=it&as_sdt=0%2C5&q=alessandra+rampazzo&btnG=
Curriculum in PDF: English CV
Articles published in the last 5 years
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Arrhythmogenic Right Ventricular Cardiomyopathy: Evaluation of the Current Diagnostic Criteria and Differential Diagnosis
EUR HEART J2020Corrado D, van Tintelen PJ, McKenna WJ, Hauer RNW, Anastastakis A, Asimaki A, Basso C, Bauce B, Brunckhorst C, Bucciarelli-Ducci C, Duru F, Elliott P, Hamilton RM, Haugaa KH, James CA, Judge D, Link MS, Marchlinski FE, Mazzanti A, Mestroni L, Pantazis A, Pelliccia A, Marra MP, Pilichou K, Platonov PGA, Protonotarios A, Rampazzo A, Saffitz JE, Saguner AM, Schmied C, Sharma S, Tandri H, Te Riele ASJM, Thiene G, Tsatsopoulou A, Zareba W, Zorzi A, Wichter T, Marcus FI, Calkins H; International Experts -
Modeling cardiovascular diseases with hipsc-derived cardiomyocytes in 2d and 3d cultures
INT J MOL SCI2020Sacchetto C, Vitiello L, de Windt LJ, Rampazzo A, Calore M -
Novel Missense Variant in MYL2 Gene Associated With Hypertrophic Cardiomyopathy Showing High Incidence of Restrictive Physiology
CIRCULATION-GENOMIC AND PRECISION MEDICINE2020De Bortoli M, Vio R, Basso C, Calore M, Minervini G, Angelini A, Melacini P, Vitiello L, Vazza G, Thiene G, Tosatto S, Corrado D, Iliceto S, Rampazzo A, Calore C -
Pathogenic Potential of Hic1-Expressing Cardiac Stromal Progenitors
CELL STEM CELL2020Soliman H, Paylor B, Scott WR, Lemos DR, Chang CK, Arostegui M, Low M, Lee C, Fiore D, Braghetta P, Pospichalova V, Barkauskas CE, Korinek V, Rampazzo A, MacLeod K, T Underhill M, Rossi FMV -
A novel murine model for arrhythmogenic cardiomyopathy points to a pathogenic role of Wnt signalling and miRNA dysregulation
CARDIOVASC RES2019Calore M, Lorenzon A, Vitiello L, Poloni G, Khan MAF, Beffagna G, Dazzo E, Sacchetto C, Polishchuk R, Sabatelli P, Doliana R, Carnevale D, Lembo G, Bonaldo P, De Windt L, Braghetta P, Rampazzo A
Research area
The research activity is focused on the biological basis of inherited cardiomyopathies. To this aim we use various approaches, ranging from genetic and genomic analyses (experimental and computational alike) to the use of in vitro and in vivo models. In particular, we study mutations and genomic variations involved in different inherited cardiomyopathies, both to identify novel disease genes and to elucidate their molecular pathogenesis. These studies are carried out with in silico genome-wide approaches, with in vitro cell culture models, and with in vivo murine disease models.
Proposals for thesis
Studies of the molecular genetics and pathogenesis of inherited cardiomyopathies. Please contact the teacher for specific information.