Chromosome Instability: Mechanisms and Health Effects, 3-4 July 2013

Final programme

July 3, Wednesday

14.30: Welcome address

14.45-17.15: Session 1 - Chromosome structural dynamics

Can chromosome integrity be maintained always and everywhere? Anna Genescà, Universitat Autònoma de Barcelona, Bellaterra, Spain

The G4 ligand RHPS4 induces chromosomal instability and increased sensitivity to X-rays in glioblastoma cells. Francesco Berardinelli, University of “Roma 3” Roma, Italy

Diverging roles of the WRN helicase and the MUS81 endonuclease in the maintenance of chromosome integrity following replication stress. Pietro Pichierri, National Institute of Health, Roma, Italy

The efficiency of Homologous Recombination and Non-Homologous End Joining systems in repairing double-strand breaks during cell cycle progression. Leonardo Bee, University of Padova, Padova, Italy

Comparative genomic hybridization studies on mesothelioma show a parallel fate of 1p21-1p22 and 9p21 bands, and a chromosomally stable sub-group. Ombretta Melaiu, University of Pisa, Italy

16.45-17.15: Coffee break

17.15-18.45: Poster viewing

17.30-18.45: SIMA General Assembly

19.00: Cocktail and music at Porta Portello


 July 4, Thursday

8.45-12.30: Session 2 - Chromosome segregation and aneuploidy

Effects of aneuploidy on chromosome segregation and cellular phenotype. Daniela Cimini, Virginia Tech, Blacksburg, VA USA

Mechanisms to maintain centromere stability in human cells. Simona Giunta The Rockfeller University, New York, USA

Inhibitors of topoisomerase 1 induce arrest of colon cancer HCT116 cells at the end of mitosis. Patrizia Vernole, University of Tor Vergata, Roma, Italy

Endogenous DNA damage and DNA repair deficiency in Down syndrome fibroblasts. Micol Tillhon, Institute of Molecular Genetics IGM-CNR, Pavia, Italy

10.15-10.45: Coffee break

Activation of the Hippo Tumor Suppressor Pathway Limits the Proliferation of Genomically Unstable Tetraploid Cells. Neil Ganem, Harvard Medical School, Boston, MA USA

Cytokinesis defects due to HIPK2 deficiency promote chromosomal instability and increase tumorigenicity. Davide Valente, Institute of Molecular Biology and Pathology-CNR, Roma, Italy

Mechanism of cancer cell killing by MPS1 inhibitors. Ilio Vitale, Regina Elena National Cancer Institute, Roma, Italy; National Institute of Health, Roma, Italy


12.00-14.30: Poster discussion and light lunch

14.30-17.00: Session 3 - Chromosome instability: past, present, and future

Chromosome Aberrations, Past, Present and Future. Adajapalam T. Natarajan, University of Tuscia, Viterbo, Italy

Genomic analysis of structural variations and methylation: possible application for studying chromosome instability. Giorgio Valle, University of Padova, Padova, Italy

Micronuclei and gene expression in a marine bivalve, Mytilus galloprovincialis. Paola Venier, University of Padova, Padova, Italy

A toxicological Ontology for the OECD QSAR Toolbox. Romualdo Benigni,
National Institute of Health, Roma, Italy

New perspectives for detecting environmentally induced genetic changes in the germ-line Francesca Pacchierotti, ENEA Casaccia, Roma, Italy

16.45: Closing address