Chromosome Instability: Mechanisms and Health Effects 3-4 July, 2013

July 3, Wednesday

14.30: Welcome address

14.45-17.15: Session 1 - Chromosome structural dynamics

14.45-15.15:
Can chromosome integrity be maintained always and everywhere? Anna Genescà, Universitat Autònoma de Barcelona, Bellaterra, Spain

15.15-15.35:
The G4 ligand RHPS4 induces chromosomal instability and increased sensitivity to X-rays in glioblastoma cells. Francesco Berardinelli, University of “Roma 3” Roma, Italy

15.35-16.05:
Diverging roles of the WRN helicase and the MUS81 endonuclease in the maintenance of chromosome integrity following replication stress. Pietro Pichierri, National Institute of Health, Roma, Italy

16.05-16.25:
The efficiency of Homologous Recombination and Non-Homologous End Joining systems in repairing double-strand breaks during cell cycle progression. Leonardo Bee, University of Padova, Padova, Italy

16.25-16.45:
Comparative genomic hybridization studies on mesothelioma show a parallel fate of 1p21-1p22 and 9p21 bands, and a chromosomally stable sub-group. Ombretta Melaiu, University of Pisa, Italy

16.45-17.15: Coffee break

17.15-18.45: Poster viewing

17.30-18.45: SIMA General Assembly

19.00: Cocktail and music at Porta Portello

 July 4, Thursday

8.45-12.30: Session 2 - Chromosome segregation and aneuploidy

8.45-9.15:
Effects of aneuploidy on chromosome segregation and cellular phenotype. Daniela Cimini, Virginia Tech, Blacksburg, VA USA

9.15-9.35:
Mechanisms to maintain centromere stability in human cells. Simona Giunta The Rockfeller University, New York, USA

9.35-9.55:
Inhibitors of topoisomerase 1 induce arrest of colon cancer HCT116 cells at the end of mitosis. Patrizia Vernole, University of Tor Vergata, Roma, Italy

9.55-10.15:
Endogenous DNA damage and DNA repair deficiency in Down syndrome fibroblasts. Micol Tillhon, Institute of Molecular Genetics IGM-CNR, Pavia, Italy

 
10.15-10.45: Coffee break

10.45-11.15:
Activation of the Hippo Tumor Suppressor Pathway Limits the Proliferation of Genomically Unstable Tetraploid Cells. Neil Ganem, Harvard Medical School, Boston, MA USA

11.15-11.35:
Cytokinesis defects due to HIPK2 deficiency promote chromosomal instability and increase tumorigenicity. Davide Valente, Institute of Molecular Biology and Pathology-CNR, Roma, Italy

11.35-11.55:
Mechanism of cancer cell killing by MPS1 inhibitors. Ilio Vitale, Regina Elena National Cancer Institute, Roma, Italy; National Institute of Health, Roma, Italy

12.00-14.30: Poster discussion and light lunch

14.30-17.00: Session 3 - Chromosome instability: past, present, and future

14.30-15.10:
Chromosome Aberrations, Past, Present and Future. Adajapalam T. Natarajan, University of Tuscia, Viterbo, Italy

15.10-15.40:
Genomic analysis of structural variations and methylation: possible application for studying chromosome instability. Giorgio Valle, University of Padova, Padova, Italy

15.40-16.00:
Micronuclei and gene expression in a marine bivalve, Mytilus galloprovincialis. Paola Venier, University of Padova, Padova, Italy

16.00-16.20:
A toxicological Ontology for the OECD QSAR Toolbox. Romualdo Benigni,
National Institute of Health, Roma, Italy

16.20-16.45:
New perspectives for detecting environmentally induced genetic changes in the germ-line Francesca Pacchierotti, ENEA Casaccia, Roma, Italy

16.45: Closing address