The Department of Biology, on behalf of the Italian Society of Environmental Mutagenesis (S.I.M.A.), organizes the workshop entitled “Chromosome instability: mechanisms and health effects”.
3-4 July, 2013
Via U.Bassi 58/ B
Viale G. Colombo 3 (pedestrian entrance)
Eukaryotic chromosomes are key players in inheritance and gene function. Chromosome architecture and mechanisms controlling chromosome distribution at mitosis and meiosis evolved to maintain the activity and stability of the genomes. Cells invest a lot of energy to protect their chromosomes integrity. Nevertheless changes occur that affect cell function and ultimately impact on health. The pioneering description of chromosome instability in cancer cells by T. Boveri, the early studies by H. Muller and B. McClintock, who independently proposed that chromosomes are protected by the integrity of their chromosome ends, the discovery of the X-ray induced effects on chromosome structure, are milestones in mutation research. One century later, the early concepts have been deeply integrated with those emerged from molecular studies on DNA damage response and repair, cell cycle control, epigenetics and genomics.
This workshop, organized on behalf of the Italian Society of Environmental Mutagenesis (SIMA), aims to focus on the most recent discoveries in the fields of structural chromosome instability, chromosome segregation and aneuploidy. A closing session is dedicated to discuss the past, present and future of fundamental and applied research on chromosome instability. Experts in the field have been invited to give a lecture. Oral contributions will be selected from the proffered abstracts to complete the programme. Young researchers will benefit of reduced registration fee.
Main topics are:
Official language of the Workshop is English
Antonella Russo (University of Padova), Francesca Degrassi (IBPM CNR, Rome), Francesca Pacchierotti (ENEA Casaccia, Rome), Sofia Pavanello (University of Padova)