MARIANO BELTRAMINI
Title: Professore ordinario
SSD: BIO/09 - Physiology
Address: VIA U. BASSI, 58/B - PADOVA
Phone: 0498276337
E-mail: mariano.beltramini@unipd.it
Teaching in current academic year
Curriculum
Graduated in Biological Sciences at the University of Padua in December 1977 (with honors), PhD in Biochemistry at the University of Zurich (1984). 1984-1987: Assistant Professor at the University of Padua; 1987-1990: Associate Professor University of Calabria; 2002-today: Full Professor of General Physiology University of Padua; 1992-2001: lecturer at the CNR Center for Metalloprotein and member of the scientific council; 1998-2002: Board of Directors and Secretary of the Italian Society of Pure and Applied Biophysics. Scientific Congress Organizations and / or Postdoctoral Schools: 1996, 2000, 2002, 2003, 2010. Research visitor: CFKR, University of Texas; Yeshiva University; University of Mainz; Bulgarian Academy of Sciences, University of Zurich. Experimental sessions at synchrotron or neutron light systems: ILL (Grenoble), ELETTRA (Trieste), ESRF (Grenoble), LBB (Paris), SOLEIL (Paris). Referee of magazines listed on JCR. Funding: MIUR (40% and COFIN, 1987-1996, 1989-1990, 1997-1999); CRUI (Project Vigoni 1996-1998; 2000-2002); CORILA (2004-2006, 2006-2008); CNR Strategic Projects (1986-1988); CNR Bilateral Projects (1986-1991, 1987-1990, 1990-1992); Joint Scientific Actions CNR-Foreign Academies (Bulgarian Academy of Sciences 1988-1990, 1991-1993; 1998-2000; Russian Academy of Medicine 1992-1993, 1994-1996, 1997-1999); ENEA (1992-1996, 1997-1999, 1999-2001); Zambon Pharmaceutics: Pilot Ex-Vivo Study: NAC-V-0I-03; PRAT (University of Padua 2005-2007; 2012-2014); EC founding BAG Biostruct-X (2013). Academic activity: President of the School of Sciences (March 2015-September 2018); Member of the University Didactic Commission (from March 2015); President of the Joint Commission of the School of Sciences (2013-2014); Vice-Dean of the Faculty of Sciences MM.FF.NN. (2009-2011); President of the Council of Study Courses in Biology and Biological Sciences (2002-2009); Representative of the Full Professors in the Department of Biology Board (2009-2011, 2011-2015); Member of the Faculty Board of Ph.D. School in Biochemistry and Biotechnology (to date Ph.D. School in Biosciences); Coordinator of the Didactic Commission of the Department of Biology (2008-March 2015); Commission for the Renewal of Research grants Macroarea 3 (2004-2007); Commission for the assignment of Projects and Research Grants (2010, 2011, 2014); Commission for the awarding of Senior Research Grant (2013); Commission for Researcher or University Professor (Univ. Bari 1992, Univ. Calabria 2001, Univ. Padova 2009, 2016, 2018); CIVR evaluation panel for research projects (2005); University Commission PRAT macroarea 3 (2010, 2011); University Equipment Commission 2015; Member of the Executive Committee of the National College of Physiology Full Professors (September 2015- Spetember 2018). Teaching activity: Since taking office as Associate Professor (1987) to date he has held courses or modules of General Physiology for five-year degrees V.O. in Biological Sciences, for bachelor degrees in Biology, in Molecular Biology, in Biotechnology, in Natural Sciences, in Biomedical Engineering, for Master Degree in Medical Biology and in Marine Biology.
Curriculum in PDF: English CV
Articles published in the last 5 years
Research area
The common research topic is the study of protein-protein interaction in the development of complex biological functions. In particular it includes both the study of the structural properties and regulation of individual protein interactors and their hierarchic interactions that govern the biological activity of protein complexes. A case study is given by hemocyanins, oxygen-binding copper proteins with complex quaternary structure. Its functional regulation is studied by allosteric metabolic modulators and its role in the mechanisms of resistance to respiratory stress. The other case study is provided by a group of proteins that play a role in neuronal physiology such as sinuclein and NSF (N-ethylmaleimide sensitive fusion protein). In the case of sinuclein the oligomerization and fibrillation processes that accompany neurodegenerative processes are under study. In the case of NSF, the implications of the interactions between NSF and multiprotein complexes in the mechanism of exocytosis of synaptic vesicles are investigated. The experimental approach combines biophysical methodologies with biochemical and biological-cellular methods. In particular, the first ones are based on the use of low-resolution techniques of giant protein complexes such as the low-angle scattering of X-rays or neutrons and different spectroscopies (X-absorption, uv-vis, IR) using synchrotron radiation plants.
Proposals for thesis
The main field of research within which it is possible to identify theses about the study of structural properties and regulation of the biological activity of complex complex proteins. A case study is given by hemocyanins, oxygen-binding copper proteins with complex quaternary structure. Its functional regulation is studied by allosteric metabolic modulators and its role in the mechanisms of resistance to respiratory stress. The other case study is provided by a group of proteins that play a role in neuronal physiology such as sinuclein and NSF (N-ethylmaleimide sensitive fusion protein). For the latter we investigate the implications of the interactions between NSF and multiprotein complexes in the mechanism of exocytosis of synaptic vesicles.