New publication - Review LRRK2 signaling in neurodegeneration: two decades of progress

Pubblicato il: 10.01.2022 09:11

LRRK2 signaling in neurodegeneration: two decades of progress

Lucia Iannotta and Elisa Greggio

Essays in Biochemistry (2021)

Parkinson’s disease is a common neurodegenerative disorder for which no cure is available. Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) cause autosomal dominant Parkinson’s and genetic variations at the LRRK2 locus are associated with sporadic disease. LRRK2 is a complex protein that orchestrates cytoskeletal dynamics and multiple steps of the endolysosomal pathway through interaction with a host of partners and phosphorylation of a subset of Rab GTPases. This review encompasses the major discoveries in the field of LRRK2 pathobiology, from the initial gene cloning to the latest progress in LRRK2 inhibition as a promising therapeutic approach to fight neurodegeneration.

Link: portlandpress.com/essaysbiochem/article-abstract/65/7/859/230434/LRRK2-signaling-in-neurodegeneration-two-decades


Ultimo aggiornamento: 10.01.2022 10:19