MADDALENA MOGNATO
Title: Professore associato
SSD: BIO/06 - Comparative Anatomy and Citology
Address: VIA U. BASSI, 58/B - PADOVA
Phone: 0498276274
E-mail: maddalena.mognato@unipd.it
Curriculum
Associate professor of Cell Biology with a Ph.D in Environmental Medicine. Her research activity is focused on cytotoxic and genotoxic effects induced in human cells by ionizing (gamma/X rays, low energy protons) and non-ionizing radiation(laser light, UV light), chemicals (nanoparticles, cisplatin, polycyclic aromatic hydrocarbons). She took part to projects funded by the Italian Space Agency to study the effects of ionizing radiation associated to modeled microgravity, focusing on DNA repair, in particular on that of double strand breaks (DSBs). She collaborated at european projects to study the cytotoxic effects and the mechanisms of action of different nanomaterials and to study the biological properties of nanosystems formuled to delivery drugs or other antineoplastic compounds, to improve selectivity and efficacy of antitumoural therapy. She collaborated with Istituto Oncologico Veneto (IOV) of Padova, the Department of Molecular Medicine and the laboratories INFN of Legnaro (PD) at the project:“Individual response to radiotherapy: looking at molecular biomarkers of radiosensitivity/radioresistance”. Since several years she studies the role of microRNA (miRNAs) as modulators of gene expression during the cell response to IR and their use as radiosensitizing agents for radioresistant human cancer cells. Her research activity is documented in international paper with referee. She participated to many international and national conferences. She has been responsible of financial grants of Padova University.
Curriculum in PDF: English CV
Research area
•Study of the DNA-Damage Response to ionizing radiation of different qualities (gamma/X rays, low energy protons) in human primary cells and cancer cells. •Analysis of gene and miRNA expression profiles in human cells exposed to genotoxic agents. Functional analysis of miRNA-mRNA interaction of DSB DNA repair. •Identification of molecular biomarkers of individual radiosensitivity in oncological patients under radiotherapy. •Nanotoxicology. Analysis of in vitro toxicity of differnt types of nanoparticles.