Padua - Mit - Innsbruck

Tuesday, September 12^th

12.30-14.00

Registration

14.00-14.20

Welcome addresses

Rosario Rizzuto – Rector of the University of Padova

Gerolamo Lanfranchi – Director of the Department of Biology, UNIPD

14.20-15.00

Keynote Lecture

Chair: Luigi Leanza

Aleksandra Trifunovic’ (University of Cologne, Germany)

TBA

15.00-16.15

Session 1: Mitochondria disorders and genome instability

Chairs: Ildikò Szabò & Diego De Stefani

15.00-15.25

ST1: Maria Pennuto (Dept. Biomedical Sciences, UNIPD)

Mitochondrial alterations and mitophagy in the muscle of SBMA patients and mice

15.25-15.50

ST2: Samantha Corrà (Dept. Biology, UNIPD)

Drosophila melanogaster as a model to study mitochondrial DNA depletion syndromes: functional characterization of dMpv17

15.50-16.15

ST3: Giovanni Rigoni (Dept. Biology, UNIPD)

Exploring the role of ATAD3A in mitochondrial function and mtDNA stability

16.15-17.00

Coffee break & Poster Session

17.00-18.40

Session 2: Mitochondria and cancer

Chairs:  Barbara Molon & Vincenzo Ciminale

17.00-17.25

ST4: Roberta Peruzzo (Dept. Biology, UNIPD)

Novel psoralen-derivatives with increased solubility in cancer treatment

17.25-17.50

ST5: Gloria Scattolin (Dept. Surgery, Oncology and Gastroenterology, UNIPD)

Mitochondrial reactive oxygen species prime T-ALL cells to apoptosis by engaging the OMA1-OPA1 axis

17.50-18.15

ST6: Giuseppe Cannino (Dept. Biomedical Sciences, UNIPD)

TRAP1 regulation in cancer metabolism: identification of new interactors

18.15-18.40

ST7: Stephanie Herkenne (VIMM, Padova)

The mitochondrial shaping protein Optic Atrophy 1 (OPA1) controls angiogenesis

20.15

Welcome cocktail & appetizers @ Caffè Pedrocchi

Wednesday, September 13^th

9.30- 10.10

Keynote Lecture (30’+10’)

Chair: Mageni Soriano

José Antonio Enríquez Domínguez (CNIC, Madrid)

TBA

10.10-11.00

Session 3: Organelle metabolism and signaling (1)

Chairs: Natascia Tiso& Luca Scorrano

10.10-10.35

ST8: Alessia Angelin (Children’s Hospital of Philadelphia, Philadelphia)

FOXP3 increases oxidative phosphorylation and NAD oxidation, adapting regulatory T cells to low glucose high lactate environments

10.35-11.00

ST9: Caterina Tezze (Dept. Biomedical Sciences, UNIPD)

Age-Associated Loss of OPA1 in Muscle Impacts Muscle Mass, Metabolic Homeostasis, Systemic Inflammation and Epithelial Senescence

11.00-11.45

Coffee break & Poster Session

11.45-13.00

Session 3: Organelle metabolism and signaling (2)

Chairs: Tito Calì& Konstantinos Lefkimmiatis

11.45-12.10

ST10: Graziano Martello (Dept. Molecular Medicine, UNIPD)

The LIF/Stat3 signal reshapes the metabolic profile of murine Embryonic Stem cells

12.10-12.35

ST11: Zampieri Sandra(Dept. Biology, UNIPD)

MCU expression levels and mitochondria dynamics in skeletal muscle of 70yrs trained seniors

12.35-13.00

ST12:Lena Pernas (Dept. Biology, UNIPD)

Mitochondria limit Toxoplasma growth by competing for fatty acids

13.00-14.30

Lunch & Poster Session

14.30-16.35

Session 4: Mitochondria quality control in health and disease

Chairs: Keiko Iwata & Marco Sandri

14.30-14.55

Invited Lecture

Maria Cavinato (Institute for Biomedical Aging Research, Innsbruck)

Involvement of mitophagy in the elimination of damaged mitochondria during the process of UVB-induced senescence

14.55-15.20

ST13: Marta Zaninello (Dept. Biology UNIPD)

A localized autophagic filter prevents entry of mitochondria carrying pathogenic Opa1 mutations in retinal ganglion cell axons

15.20-15.45

ST14: Cristina Catoni (Dept. Biology, UNIPD)

Detect protein kinase A (PKA) distribution at the sub-mitochondrial level with a new molecular tool

15.45-16.10

ST15: Martina La Spina (Dept. Biomedical Sciences, UNIPD)

Induction of autophagy and mitochondrial biogenesis by the natural compound Pterostilbene: mechanisms and biomedical potential

16.10-16.35

ST16: Sophia von Stockum (Dept. Biology, UNIPD)

Inhibition of the deubiquitinase USP8 corrects a PINK1 loss of function model of Parkinson’s Disease by normalizing mitochondrial respiratory complexes

16.35-17.00

Coffee Break & Poster Session

17.00-18.40

Session 5: Mitochondrial Bioenergetic

Chairs: Eva Trevisson& Leonardo Salviati

17.00-17.25

ST17: Rubén Quintana-Cabrera (Institute of Functional Biology and Genomics (IBFG), University of Salamanca-CSIC, Spain)

Cyclophilin D impinges on ATPase to define mitochondrial cristae shape and transition pore occurence

17.25-17.50

ST18: Vanessa Checchetto (Dept. Biology, UNIPD)

Biophysical and pharmacological characterization of a channel-forming mitochondrial protein complex

17.50-18.15

ST19: Angela Paggio (Dept. Biomedical Sciences, UNIPD)

Identification of ATP-sensitive potassium channels in the inner mitochondrial membrane

18.15 -18.40

ST20: Manuel Acosta Lopez (Department of Women and Children’s Health, UNIPD)

Biochemical and physiological characterization of the effect of Vanillic Acid in a COQ6 KO mammalian cell line

20.30

Social dinner @ Q Bar

Thursday, September 14^th

9.30- 10.10

Keynote Lecture

Chair: Elena Ziviani

Thomas Langer (University of Cologne, Germany)

Proteolytic control of mitochondrial dynamics

10.10-10.30

Sponsor Talk (Agilent) (15’+5’)

Chair: Rubèn Quintana-Cabrera

Dr. Emma Di Capua

Measuring Mitochondrial Function and Glycolysis using the Seahorse XF Analyzers

10.30-11.10

Coffee break & Poster Session

11.10-12.50

Session 6: Mitochondrial dynamics and interorganelle interaction

Chairs: Marisa Brini & Marta Giacomello

11.10-11.35

ST21: Domenico Cieri (Dept. Biomedical Sciences, UNIPD)

SPLICS: a split green fluorescent protein-based contact site sensor for narrow and wide heterotypic organelle juxtaposition

11.35-12.00

ST22: Valentina Basso (Dept. Biology, UNIPD)

To ubiquitinate or not to ubiquitinate? The regulation of ER-Mitochondria tether in an in vivo animal model of Parkinson's Disease

12.00-12.25

ST23: Gaia Gherardi (Dept. Biomedical Sciences, UNIPD)

The physiopathological role of mitochondrial calcium uptake in skeletal muscle homeostasis

12.25-12.50

ST24: Andrielly H.R. Agnellini (Dept. Biomedical Sciences, UNIPD)

Mitochondrial dynamics in macrophage biology

12.50-13.30

Concluding Remarks by Christoph Schwarzer (Dept. of Pharmacology, Innsbruck)